local erythropoietin injection in tibiofibular fracture healing
نویسندگان
چکیده
conclusions epo injection into the site of tibiofibular fractures may possibly accelerate healing. background erythropoietin (epo), in addition to its function as an erythropoiesis regulator has a regenerative activity on some nonhematopoietic tissues. animal studies have suggested a role for erythropoietin in bone healing. objectives the present study aimed to evaluate the effects of local epo injection in healing of tibiofibular fractures. materials and methods in a prospective double blind study, 60 patients with tibiofibular fracture were divided to equal epo or placebo groups, randomly. patients received local injection of either epo or a placebo to the site of fracture two weeks after surgical fixation. patients were followed by clinical and radiographic examination to determine the :union: rate. the period of fracture :union: and incidence of non:union: were compared between the two groups. results the demographic data and types of fractures were similar in the both groups. the mean duration of the fracture :union: was 2.1 weeks shorter in those treated with epo (p = 0.01). non:union: was observed in 6 patients of the control group and 2 receiving epo (p = 0.02). no patient experienced any adverse effect from local epo injections.
منابع مشابه
Local Erythropoietin Injection in Tibiofibular Fracture Healing
BACKGROUND Erythropoietin (EPO), in addition to its function as an erythropoiesis regulator has a regenerative activity on some nonhematopoietic tissues. Animal studies have suggested a role for erythropoietin in bone healing. OBJECTIVES The present study aimed to evaluate the effects of local EPO injection in healing of tibiofibular fractures. MATERIALS AND METHODS In a prospective double ...
متن کاملQueries Regarding Local Erythropoietin Injection in Tibiofibular Fracture Healing
We would like to congratulate Dr. Bakhshi and colleagues for being the first group to publish scientific evidence regarding the osteogenic effect of erythropoietin (EPO) in a clinical trial (1). As you correctly report, several preclinical studies have shown the efficacy of Erythropoietin to increase bone healing at early time points (2-4).In agreement with your approach, we strongly believe th...
متن کاملIn Reply to: Queries Regarding Local Erythropoietin Injection in Tibiofibular Fracture Healing
In replyWe would like to thank Dr. Duedal Rölfing for his keen observations. We hope that this study encourages prospective scientific publications. Erythropoietin (EPO) is a glycoprotein produced by the kidney which promotes the formation of red blood cells in the bone marrow. Recent studies have determined additional roles of EPO in tissue survival and cellular proliferation (1-3). EPO may ac...
متن کاملin reply to: queries regarding local erythropoietin injection in tibiofibular fracture healing
متن کامل
Effects of erythropoietin on fracture healing in rats.
F healing and the factors affecting it has always attracted researchers’ curiosity. Fracture healing is a complex process, local (mechanical, physical, chemical, environmental), and systemic (hormonal factors, vitamins, drugs, systemic growth factors, diseases) factors all play a part at each stage. Although the histopathological process of fracture healing is now almost completely understood, ...
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عنوان ژورنال:
trauma monthlyجلد ۱۷، شماره ۴، صفحات ۳۸۶-۸
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